1.
Hepatobiliary Surg Nutr
; 13(2): 325-328, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38617473
2.
Oncoimmunology
; 13(1): 2326694, 2024.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38481728
RESUMO
Pancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane (tm)TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T-cell dysfunction - two hallmarks of therapeutic resistance. Targeting tmTNF-TNFR2 signaling may sensitize pancreatic cancer to chemo±immunotherapy.